When does atopic dermatitis warrant systemic therapy? Recommendations from an expert panel of the International Eczema Council.
Identifieur interne : 000046 ( Main/Exploration ); précédent : 000045; suivant : 000047When does atopic dermatitis warrant systemic therapy? Recommendations from an expert panel of the International Eczema Council.
Auteurs : Eric L. Simpson [États-Unis] ; Marjolein Bruin-Weller [Pays-Bas] ; Carsten Flohr [Royaume-Uni] ; Michael R. Ardern-Jones [Royaume-Uni] ; Sebastien Barbarot [France] ; Mette Deleuran [Danemark] ; Thomas Bieber [Suisse] ; Christian Vestergaard [Danemark] ; Sara J. Brown [Royaume-Uni] ; Michael J. Cork [Royaume-Uni] ; Aaron M. Drucker [États-Unis] ; Lawrence F. Eichenfield [États-Unis] ; Regina Foelster-Holst [Allemagne] ; Emma Guttman-Yassky [États-Unis] ; Audrey Nosbaum [France] ; Nick J. Reynolds [Royaume-Uni] ; Jonathan I. Silverberg [États-Unis] ; Jochen Schmitt [Allemagne] ; Marieke M B. Seyger [Pays-Bas] ; Phyllis I. Spuls [Pays-Bas] ; Jean-Francois Stalder [France] ; John C. Su [Australie] ; Roberto Takaoka [Brésil] ; Claudia Traidl-Hoffmann [Suisse] ; Jacob P. Thyssen [Danemark] ; Jorien Van Der Schaft [Allemagne] ; Andreas Wollenberg [Allemagne] ; Alan D. Irvine [Royaume-Uni] ; Amy S. Paller [États-Unis]Source :
- Journal of the American Academy of Dermatology [ 1097-6787 ] ; 2017.
Descripteurs français
- KwdFr :
- Administration par voie cutanée, Administration par voie orale, Eczéma atopique (), Eczéma atopique (diagnostic), Eczéma atopique (traitement médicamenteux), Humains, Immunosuppresseurs (administration et posologie), Immunosuppresseurs (usage thérapeutique), Indice de gravité médicale, Injections, Photothérapie, Prise de décision clinique, Produits biologiques (usage thérapeutique), Produits dermatologiques (administration et posologie), Qualité de vie, Éducation du patient comme sujet.
- MESH :
- administration et posologie : Immunosuppresseurs, Produits dermatologiques.
- diagnostic : Eczéma atopique.
- traitement médicamenteux : Eczéma atopique.
- usage thérapeutique : Immunosuppresseurs, Produits biologiques.
- Administration par voie cutanée, Administration par voie orale, Eczéma atopique, Humains, Indice de gravité médicale, Injections, Photothérapie, Prise de décision clinique, Qualité de vie, Éducation du patient comme sujet.
English descriptors
- KwdEn :
- Administration, Cutaneous, Administration, Oral, Biological Products (therapeutic use), Clinical Decision-Making, Dermatitis, Atopic (diagnosis), Dermatitis, Atopic (drug therapy), Dermatitis, Atopic (therapy), Dermatologic Agents (administration & dosage), Humans, Immunosuppressive Agents (administration & dosage), Immunosuppressive Agents (therapeutic use), Injections, Patient Education as Topic, Phototherapy, Quality of Life, Severity of Illness Index.
- MESH :
- chemical , administration & dosage : Dermatologic Agents, Immunosuppressive Agents.
- chemical , therapeutic use : Biological Products, Immunosuppressive Agents.
- diagnosis : Dermatitis, Atopic.
- drug therapy : Dermatitis, Atopic.
- therapy : Dermatitis, Atopic.
- Administration, Cutaneous, Administration, Oral, Clinical Decision-Making, Humans, Injections, Patient Education as Topic, Phototherapy, Quality of Life, Severity of Illness Index.
Abstract
Although most patients with atopic dermatitis (AD) are effectively managed with topical medication, a significant minority require systemic therapy. Guidelines for decision making about advancement to systemic therapy are lacking.
DOI: 10.1016/j.jaad.2017.06.042
PubMed: 28803668
Affiliations:
- Allemagne, Australie, Brésil, Danemark, France, Pays-Bas, Royaume-Uni, Suisse, États-Unis
- Angleterre, Auvergne-Rhône-Alpes, Bavière, Californie, District de Dresde, District de Haute-Bavière, Grand Londres, Gueldre, Hollande-Septentrionale, Illinois, Oregon, Pays de la Loire, Rhode Island, Rhône-Alpes, Saxe (Land), Schleswig-Holstein, Utrecht (province), Victoria (État), État de New York, État de São Paulo
- Amsterdam, Dresde, Kiel, Londres, Lyon, Melbourne, Munich, Nantes, Nimègue, São Paulo, Utrecht
- Université technique de Dresde
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Le document en format XML
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Brown</name><affiliation wicri:level="1"><nlm:affiliation>Skin Research Group, School of Medicine, University of Dundee, Dundee, United Kingdom; Department of Dermatology, Ninewells Hospital and Medical School, Dundee, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Skin Research Group, School of Medicine, University of Dundee, Dundee, United Kingdom; Department of Dermatology, Ninewells Hospital and Medical School, Dundee</wicri:regionArea><wicri:noRegion>Dundee</wicri:noRegion></affiliation></author><author><name sortKey="Cork, Michael J" sort="Cork, Michael J" uniqKey="Cork M" first="Michael J" last="Cork">Michael J. Cork</name><affiliation wicri:level="1"><nlm:affiliation>Sheffield Dermatology Research Department of Infection, Immunity and Cardiovascular Disease, The University of Sheffield, Sheffield, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sheffield Dermatology Research Department of Infection, Immunity and Cardiovascular Disease, The University of Sheffield, Sheffield</wicri:regionArea><wicri:noRegion>Sheffield</wicri:noRegion></affiliation></author><author><name sortKey="Drucker, Aaron M" sort="Drucker, Aaron M" uniqKey="Drucker A" first="Aaron M" last="Drucker">Aaron M. Drucker</name><affiliation wicri:level="2"><nlm:affiliation>Department of Dermatology, Alpert Medical School of Brown University, Providence, Rhode Island.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Rhode Island</region></placeName><wicri:cityArea>Department of Dermatology, Alpert Medical School of Brown University, Providence</wicri:cityArea></affiliation></author><author><name sortKey="Eichenfield, Lawrence F" sort="Eichenfield, Lawrence F" uniqKey="Eichenfield L" first="Lawrence F" last="Eichenfield">Lawrence F. Eichenfield</name><affiliation wicri:level="2"><nlm:affiliation>Department of Dermatology, University of California, San Diego, California; Department of Pediatrics, University of California, San Diego, California; Rady Children's Hospital, San Diego, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Dermatology, University of California, San Diego, California; Department of Pediatrics, University of California, San Diego, California; Rady Children's Hospital, San Diego</wicri:cityArea></affiliation></author><author><name sortKey="Foelster Holst, Regina" sort="Foelster Holst, Regina" uniqKey="Foelster Holst R" first="Regina" last="Foelster-Holst">Regina Foelster-Holst</name><affiliation wicri:level="3"><nlm:affiliation>Dermatology, Venereology and Allergology, University of Schleswig-Holstein, Kiel, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Dermatology, Venereology and Allergology, University of Schleswig-Holstein, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Guttman Yassky, Emma" sort="Guttman Yassky, Emma" uniqKey="Guttman Yassky E" first="Emma" last="Guttman-Yassky">Emma Guttman-Yassky</name><affiliation wicri:level="2"><nlm:affiliation>Icahn School of Medicine at Mount Sinai Medical Center, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Icahn School of Medicine at Mount Sinai Medical Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Nosbaum, Audrey" sort="Nosbaum, Audrey" uniqKey="Nosbaum A" first="Audrey" last="Nosbaum">Audrey Nosbaum</name><affiliation wicri:level="3"><nlm:affiliation>Department of Allergy and Clinical Immunology, University Hospital Lyon Sud, Hospices Civiles de Lyon, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Allergy and Clinical Immunology, University Hospital Lyon Sud, Hospices Civiles de Lyon, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Reynolds, Nick J" sort="Reynolds, Nick J" uniqKey="Reynolds N" first="Nick J" last="Reynolds">Nick J. Reynolds</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; Newcastle Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; Newcastle Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne</wicri:regionArea><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Silverberg, Jonathan I" sort="Silverberg, Jonathan I" uniqKey="Silverberg J" first="Jonathan I" last="Silverberg">Jonathan I. Silverberg</name><affiliation wicri:level="2"><nlm:affiliation>Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Schmitt, Jochen" sort="Schmitt, Jochen" uniqKey="Schmitt J" first="Jochen" last="Schmitt">Jochen Schmitt</name><affiliation wicri:level="4"><nlm:affiliation>Center for Evidence-Based Healthcare, Technische Universität Dresden, Dresden, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center for Evidence-Based Healthcare, Technische Universität Dresden, Dresden</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Dresde</region><settlement type="city">Dresde</settlement><settlement type="city">Dresde</settlement></placeName><orgName type="university">Université technique de Dresde</orgName></affiliation></author><author><name sortKey="Seyger, Marieke M B" sort="Seyger, Marieke M B" uniqKey="Seyger M" first="Marieke M B" last="Seyger">Marieke M B. Seyger</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Spuls, Phyllis I" sort="Spuls, Phyllis I" uniqKey="Spuls P" first="Phyllis I" last="Spuls">Phyllis I. Spuls</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, Academic Medical Centre, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Dermatology, Academic Medical Centre, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Stalder, Jean Francois" sort="Stalder, Jean Francois" uniqKey="Stalder J" first="Jean-Francois" last="Stalder">Jean-Francois Stalder</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, Nantes University Hospital, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Dermatology, Nantes University Hospital, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Su, John C" sort="Su, John C" uniqKey="Su J" first="John C" last="Su">John C. Su</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, Monash University, Eastern Health and Murdoch Childrens Research Institute, University of Melbourne, Melbourne, Australia; Department of Paediatrics, Monash University, Eastern Health and Murdoch Childrens Research Institute, University of Melbourne, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Dermatology, Monash University, Eastern Health and Murdoch Childrens Research Institute, University of Melbourne, Melbourne, Australia; Department of Paediatrics, Monash University, Eastern Health and Murdoch Childrens Research Institute, University of Melbourne, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Takaoka, Roberto" sort="Takaoka, Roberto" uniqKey="Takaoka R" first="Roberto" last="Takaoka">Roberto Takaoka</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, University of São Paulo Medical School, São Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Dermatology, University of São Paulo Medical School, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Traidl Hoffmann, Claudia" sort="Traidl Hoffmann, Claudia" uniqKey="Traidl Hoffmann C" first="Claudia" last="Traidl-Hoffmann">Claudia Traidl-Hoffmann</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Environmental Medicine, UNIKA-T, Technical University of Munich and Helmholtz Zentrum München-German Research Center for Environmental Health (GmbH), Munich, Germany; CK CARE, Christine-Kühne-Center for Allergy Research and Education, Davos, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Environmental Medicine, UNIKA-T, Technical University of Munich and Helmholtz Zentrum München-German Research Center for Environmental Health (GmbH), Munich, Germany; CK CARE, Christine-Kühne-Center for Allergy Research and Education, Davos</wicri:regionArea><wicri:noRegion>Davos</wicri:noRegion></affiliation></author><author><name sortKey="Thyssen, Jacob P" sort="Thyssen, Jacob P" uniqKey="Thyssen J" first="Jacob P" last="Thyssen">Jacob P. Thyssen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Dermatology and Allergy, Herlev-Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Dermatology and Allergy, Herlev-Gentofte Hospital, University of Copenhagen, Hellerup</wicri:regionArea><wicri:noRegion>Hellerup</wicri:noRegion></affiliation></author><author><name sortKey="Van Der Schaft, Jorien" sort="Van Der Schaft, Jorien" uniqKey="Van Der Schaft J" first="Jorien" last="Van Der Schaft">Jorien Van Der Schaft</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology and Allergology, University Medical Centre Utrech, Utrecht, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Dermatology and Allergology, University Medical Centre Utrech, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Wollenberg, Andreas" sort="Wollenberg, Andreas" uniqKey="Wollenberg A" first="Andreas" last="Wollenberg">Andreas Wollenberg</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology and Allergy, Ludwig-Maximilian-University Munich, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Dermatology and Allergy, Ludwig-Maximilian-University Munich, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Irvine, Alan D" sort="Irvine, Alan D" uniqKey="Irvine A" first="Alan D" last="Irvine">Alan D. Irvine</name><affiliation wicri:level="1"><nlm:affiliation>Trinity College Dublin, National Children's Research Centre, Paediatric Dermatology Our Lady's Children's Hospital, Dublin, United Kingdom. Electronic address: irvinea@tcd.ie.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Trinity College Dublin, National Children's Research Centre, Paediatric Dermatology Our Lady's Children's Hospital, Dublin</wicri:regionArea><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Paller, Amy S" sort="Paller, Amy S" uniqKey="Paller A" first="Amy S" last="Paller">Amy S. Paller</name><affiliation wicri:level="2"><nlm:affiliation>Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois. Electronic address: apaller@northwestern.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28803668</idno><idno type="pmid">28803668</idno><idno type="doi">10.1016/j.jaad.2017.06.042</idno><idno type="wicri:Area/PubMed/Corpus">000297</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000297</idno><idno type="wicri:Area/PubMed/Curation">000295</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000295</idno><idno type="wicri:Area/PubMed/Checkpoint">000295</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000295</idno><idno type="wicri:Area/Ncbi/Merge">004C84</idno><idno type="wicri:Area/Ncbi/Curation">004C84</idno><idno type="wicri:Area/Ncbi/Checkpoint">004C84</idno><idno type="wicri:Area/Main/Merge">000041</idno><idno type="wicri:Area/Main/Curation">000046</idno><idno type="wicri:Area/Main/Exploration">000046</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">When does atopic dermatitis warrant systemic therapy? Recommendations from an expert panel of the International Eczema Council.</title><author><name sortKey="Simpson, Eric L" sort="Simpson, Eric L" uniqKey="Simpson E" first="Eric L" last="Simpson">Eric L. Simpson</name><affiliation wicri:level="2"><nlm:affiliation>Department of Dermatology, Oregon Health and Science University, Portland, Oregon. Electronic address: simpsone@ohsu.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oregon</region></placeName><wicri:cityArea>Department of Dermatology, Oregon Health and Science University, Portland</wicri:cityArea></affiliation></author><author><name sortKey="Bruin Weller, Marjolein" sort="Bruin Weller, Marjolein" uniqKey="Bruin Weller M" first="Marjolein" last="Bruin-Weller">Marjolein Bruin-Weller</name><affiliation wicri:level="3"><nlm:affiliation>National Expertise Center for Atopic Dermatitis, Department of Dermatology and Allergology, University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>National Expertise Center for Atopic Dermatitis, Department of Dermatology and Allergology, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Flohr, Carsten" sort="Flohr, Carsten" uniqKey="Flohr C" first="Carsten" last="Flohr">Carsten Flohr</name><affiliation wicri:level="3"><nlm:affiliation>Unit for Population-Based Dermatology Research, St John's Institute of Dermatology, Guy's and St Thomas' National Health Service Foundation Trust and King's College London, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Unit for Population-Based Dermatology Research, St John's Institute of Dermatology, Guy's and St Thomas' National Health Service Foundation Trust and King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Ardern Jones, Michael R" sort="Ardern Jones, Michael R" uniqKey="Ardern Jones M" first="Michael R" last="Ardern-Jones">Michael R. Ardern-Jones</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton</wicri:regionArea><wicri:noRegion>Southampton</wicri:noRegion></affiliation></author><author><name sortKey="Barbarot, Sebastien" sort="Barbarot, Sebastien" uniqKey="Barbarot S" first="Sebastien" last="Barbarot">Sebastien Barbarot</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, Nantes University Hospital, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Dermatology, Nantes University Hospital, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Deleuran, Mette" sort="Deleuran, Mette" uniqKey="Deleuran M" first="Mette" last="Deleuran">Mette Deleuran</name><affiliation wicri:level="1"><nlm:affiliation>Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Dermatology, Aarhus University Hospital, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Bieber, Thomas" sort="Bieber, Thomas" uniqKey="Bieber T" first="Thomas" last="Bieber">Thomas Bieber</name><affiliation wicri:level="1"><nlm:affiliation>Department of Dermatology and Allergy, University of Bonn, Bonn, Germany; Christine Kühne-Center for Allergy Research and Education, Davos, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Dermatology and Allergy, University of Bonn, Bonn, Germany; Christine Kühne-Center for Allergy Research and Education, Davos</wicri:regionArea><wicri:noRegion>Davos</wicri:noRegion></affiliation></author><author><name sortKey="Vestergaard, Christian" sort="Vestergaard, Christian" uniqKey="Vestergaard C" first="Christian" last="Vestergaard">Christian Vestergaard</name><affiliation wicri:level="1"><nlm:affiliation>Department of Dermatology Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Dermatology Aarhus University Hospital, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Brown, Sara J" sort="Brown, Sara J" uniqKey="Brown S" first="Sara J" last="Brown">Sara J. Brown</name><affiliation wicri:level="1"><nlm:affiliation>Skin Research Group, School of Medicine, University of Dundee, Dundee, United Kingdom; Department of Dermatology, Ninewells Hospital and Medical School, Dundee, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Skin Research Group, School of Medicine, University of Dundee, Dundee, United Kingdom; Department of Dermatology, Ninewells Hospital and Medical School, Dundee</wicri:regionArea><wicri:noRegion>Dundee</wicri:noRegion></affiliation></author><author><name sortKey="Cork, Michael J" sort="Cork, Michael J" uniqKey="Cork M" first="Michael J" last="Cork">Michael J. Cork</name><affiliation wicri:level="1"><nlm:affiliation>Sheffield Dermatology Research Department of Infection, Immunity and Cardiovascular Disease, The University of Sheffield, Sheffield, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sheffield Dermatology Research Department of Infection, Immunity and Cardiovascular Disease, The University of Sheffield, Sheffield</wicri:regionArea><wicri:noRegion>Sheffield</wicri:noRegion></affiliation></author><author><name sortKey="Drucker, Aaron M" sort="Drucker, Aaron M" uniqKey="Drucker A" first="Aaron M" last="Drucker">Aaron M. Drucker</name><affiliation wicri:level="2"><nlm:affiliation>Department of Dermatology, Alpert Medical School of Brown University, Providence, Rhode Island.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Rhode Island</region></placeName><wicri:cityArea>Department of Dermatology, Alpert Medical School of Brown University, Providence</wicri:cityArea></affiliation></author><author><name sortKey="Eichenfield, Lawrence F" sort="Eichenfield, Lawrence F" uniqKey="Eichenfield L" first="Lawrence F" last="Eichenfield">Lawrence F. Eichenfield</name><affiliation wicri:level="2"><nlm:affiliation>Department of Dermatology, University of California, San Diego, California; Department of Pediatrics, University of California, San Diego, California; Rady Children's Hospital, San Diego, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Dermatology, University of California, San Diego, California; Department of Pediatrics, University of California, San Diego, California; Rady Children's Hospital, San Diego</wicri:cityArea></affiliation></author><author><name sortKey="Foelster Holst, Regina" sort="Foelster Holst, Regina" uniqKey="Foelster Holst R" first="Regina" last="Foelster-Holst">Regina Foelster-Holst</name><affiliation wicri:level="3"><nlm:affiliation>Dermatology, Venereology and Allergology, University of Schleswig-Holstein, Kiel, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Dermatology, Venereology and Allergology, University of Schleswig-Holstein, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Guttman Yassky, Emma" sort="Guttman Yassky, Emma" uniqKey="Guttman Yassky E" first="Emma" last="Guttman-Yassky">Emma Guttman-Yassky</name><affiliation wicri:level="2"><nlm:affiliation>Icahn School of Medicine at Mount Sinai Medical Center, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Icahn School of Medicine at Mount Sinai Medical Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Nosbaum, Audrey" sort="Nosbaum, Audrey" uniqKey="Nosbaum A" first="Audrey" last="Nosbaum">Audrey Nosbaum</name><affiliation wicri:level="3"><nlm:affiliation>Department of Allergy and Clinical Immunology, University Hospital Lyon Sud, Hospices Civiles de Lyon, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Allergy and Clinical Immunology, University Hospital Lyon Sud, Hospices Civiles de Lyon, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Reynolds, Nick J" sort="Reynolds, Nick J" uniqKey="Reynolds N" first="Nick J" last="Reynolds">Nick J. Reynolds</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; Newcastle Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; Newcastle Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne</wicri:regionArea><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Silverberg, Jonathan I" sort="Silverberg, Jonathan I" uniqKey="Silverberg J" first="Jonathan I" last="Silverberg">Jonathan I. Silverberg</name><affiliation wicri:level="2"><nlm:affiliation>Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Schmitt, Jochen" sort="Schmitt, Jochen" uniqKey="Schmitt J" first="Jochen" last="Schmitt">Jochen Schmitt</name><affiliation wicri:level="4"><nlm:affiliation>Center for Evidence-Based Healthcare, Technische Universität Dresden, Dresden, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center for Evidence-Based Healthcare, Technische Universität Dresden, Dresden</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Dresde</region><settlement type="city">Dresde</settlement><settlement type="city">Dresde</settlement></placeName><orgName type="university">Université technique de Dresde</orgName></affiliation></author><author><name sortKey="Seyger, Marieke M B" sort="Seyger, Marieke M B" uniqKey="Seyger M" first="Marieke M B" last="Seyger">Marieke M B. Seyger</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Spuls, Phyllis I" sort="Spuls, Phyllis I" uniqKey="Spuls P" first="Phyllis I" last="Spuls">Phyllis I. Spuls</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, Academic Medical Centre, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Dermatology, Academic Medical Centre, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Stalder, Jean Francois" sort="Stalder, Jean Francois" uniqKey="Stalder J" first="Jean-Francois" last="Stalder">Jean-Francois Stalder</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, Nantes University Hospital, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Dermatology, Nantes University Hospital, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Su, John C" sort="Su, John C" uniqKey="Su J" first="John C" last="Su">John C. Su</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, Monash University, Eastern Health and Murdoch Childrens Research Institute, University of Melbourne, Melbourne, Australia; Department of Paediatrics, Monash University, Eastern Health and Murdoch Childrens Research Institute, University of Melbourne, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Dermatology, Monash University, Eastern Health and Murdoch Childrens Research Institute, University of Melbourne, Melbourne, Australia; Department of Paediatrics, Monash University, Eastern Health and Murdoch Childrens Research Institute, University of Melbourne, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Takaoka, Roberto" sort="Takaoka, Roberto" uniqKey="Takaoka R" first="Roberto" last="Takaoka">Roberto Takaoka</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, University of São Paulo Medical School, São Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Dermatology, University of São Paulo Medical School, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Traidl Hoffmann, Claudia" sort="Traidl Hoffmann, Claudia" uniqKey="Traidl Hoffmann C" first="Claudia" last="Traidl-Hoffmann">Claudia Traidl-Hoffmann</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Environmental Medicine, UNIKA-T, Technical University of Munich and Helmholtz Zentrum München-German Research Center for Environmental Health (GmbH), Munich, Germany; CK CARE, Christine-Kühne-Center for Allergy Research and Education, Davos, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Environmental Medicine, UNIKA-T, Technical University of Munich and Helmholtz Zentrum München-German Research Center for Environmental Health (GmbH), Munich, Germany; CK CARE, Christine-Kühne-Center for Allergy Research and Education, Davos</wicri:regionArea><wicri:noRegion>Davos</wicri:noRegion></affiliation></author><author><name sortKey="Thyssen, Jacob P" sort="Thyssen, Jacob P" uniqKey="Thyssen J" first="Jacob P" last="Thyssen">Jacob P. Thyssen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Dermatology and Allergy, Herlev-Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Dermatology and Allergy, Herlev-Gentofte Hospital, University of Copenhagen, Hellerup</wicri:regionArea><wicri:noRegion>Hellerup</wicri:noRegion></affiliation></author><author><name sortKey="Van Der Schaft, Jorien" sort="Van Der Schaft, Jorien" uniqKey="Van Der Schaft J" first="Jorien" last="Van Der Schaft">Jorien Van Der Schaft</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology and Allergology, University Medical Centre Utrech, Utrecht, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Dermatology and Allergology, University Medical Centre Utrech, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Wollenberg, Andreas" sort="Wollenberg, Andreas" uniqKey="Wollenberg A" first="Andreas" last="Wollenberg">Andreas Wollenberg</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology and Allergy, Ludwig-Maximilian-University Munich, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Dermatology and Allergy, Ludwig-Maximilian-University Munich, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Irvine, Alan D" sort="Irvine, Alan D" uniqKey="Irvine A" first="Alan D" last="Irvine">Alan D. Irvine</name><affiliation wicri:level="1"><nlm:affiliation>Trinity College Dublin, National Children's Research Centre, Paediatric Dermatology Our Lady's Children's Hospital, Dublin, United Kingdom. Electronic address: irvinea@tcd.ie.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Trinity College Dublin, National Children's Research Centre, Paediatric Dermatology Our Lady's Children's Hospital, Dublin</wicri:regionArea><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Paller, Amy S" sort="Paller, Amy S" uniqKey="Paller A" first="Amy S" last="Paller">Amy S. Paller</name><affiliation wicri:level="2"><nlm:affiliation>Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois. Electronic address: apaller@northwestern.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago</wicri:cityArea></affiliation></author></analytic><series><title level="j">Journal of the American Academy of Dermatology</title><idno type="eISSN">1097-6787</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Cutaneous</term><term>Administration, Oral</term><term>Biological Products (therapeutic use)</term><term>Clinical Decision-Making</term><term>Dermatitis, Atopic (diagnosis)</term><term>Dermatitis, Atopic (drug therapy)</term><term>Dermatitis, Atopic (therapy)</term><term>Dermatologic Agents (administration & dosage)</term><term>Humans</term><term>Immunosuppressive Agents (administration & dosage)</term><term>Immunosuppressive Agents (therapeutic use)</term><term>Injections</term><term>Patient Education as Topic</term><term>Phototherapy</term><term>Quality of Life</term><term>Severity of Illness Index</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Administration par voie cutanée</term><term>Administration par voie orale</term><term>Eczéma atopique ()</term><term>Eczéma atopique (diagnostic)</term><term>Eczéma atopique (traitement médicamenteux)</term><term>Humains</term><term>Immunosuppresseurs (administration et posologie)</term><term>Immunosuppresseurs (usage thérapeutique)</term><term>Indice de gravité médicale</term><term>Injections</term><term>Photothérapie</term><term>Prise de décision clinique</term><term>Produits biologiques (usage thérapeutique)</term><term>Produits dermatologiques (administration et posologie)</term><term>Qualité de vie</term><term>Éducation du patient comme sujet</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Dermatologic Agents</term><term>Immunosuppressive Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Biological Products</term><term>Immunosuppressive Agents</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Immunosuppresseurs</term><term>Produits dermatologiques</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Dermatitis, Atopic</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Eczéma atopique</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Dermatitis, Atopic</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Dermatitis, Atopic</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Eczéma atopique</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Immunosuppresseurs</term><term>Produits biologiques</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Cutaneous</term><term>Administration, Oral</term><term>Clinical Decision-Making</term><term>Humans</term><term>Injections</term><term>Patient Education as Topic</term><term>Phototherapy</term><term>Quality of Life</term><term>Severity of Illness Index</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Administration par voie cutanée</term><term>Administration par voie orale</term><term>Eczéma atopique</term><term>Humains</term><term>Indice de gravité médicale</term><term>Injections</term><term>Photothérapie</term><term>Prise de décision clinique</term><term>Qualité de vie</term><term>Éducation du patient comme sujet</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Although most patients with atopic dermatitis (AD) are effectively managed with topical medication, a significant minority require systemic therapy. Guidelines for decision making about advancement to systemic therapy are lacking.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Brésil</li><li>Danemark</li><li>France</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Suisse</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Auvergne-Rhône-Alpes</li><li>Bavière</li><li>Californie</li><li>District de Dresde</li><li>District de Haute-Bavière</li><li>Grand Londres</li><li>Gueldre</li><li>Hollande-Septentrionale</li><li>Illinois</li><li>Oregon</li><li>Pays de la Loire</li><li>Rhode Island</li><li>Rhône-Alpes</li><li>Saxe (Land)</li><li>Schleswig-Holstein</li><li>Utrecht (province)</li><li>Victoria (État)</li><li>État de New York</li><li>État de São Paulo</li></region><settlement><li>Amsterdam</li><li>Dresde</li><li>Kiel</li><li>Londres</li><li>Lyon</li><li>Melbourne</li><li>Munich</li><li>Nantes</li><li>Nimègue</li><li>São Paulo</li><li>Utrecht</li></settlement><orgName><li>Université technique de Dresde</li></orgName></list><tree><country name="États-Unis"><region name="Oregon"><name sortKey="Simpson, Eric L" sort="Simpson, Eric L" uniqKey="Simpson E" first="Eric L" last="Simpson">Eric L. Simpson</name></region><name sortKey="Drucker, Aaron M" sort="Drucker, Aaron M" uniqKey="Drucker A" first="Aaron M" last="Drucker">Aaron M. Drucker</name><name sortKey="Eichenfield, Lawrence F" sort="Eichenfield, Lawrence F" uniqKey="Eichenfield L" first="Lawrence F" last="Eichenfield">Lawrence F. Eichenfield</name><name sortKey="Guttman Yassky, Emma" sort="Guttman Yassky, Emma" uniqKey="Guttman Yassky E" first="Emma" last="Guttman-Yassky">Emma Guttman-Yassky</name><name sortKey="Paller, Amy S" sort="Paller, Amy S" uniqKey="Paller A" first="Amy S" last="Paller">Amy S. Paller</name><name sortKey="Silverberg, Jonathan I" sort="Silverberg, Jonathan I" uniqKey="Silverberg J" first="Jonathan I" last="Silverberg">Jonathan I. Silverberg</name></country><country name="Pays-Bas"><region name="Utrecht (province)"><name sortKey="Bruin Weller, Marjolein" sort="Bruin Weller, Marjolein" uniqKey="Bruin Weller M" first="Marjolein" last="Bruin-Weller">Marjolein Bruin-Weller</name></region><name sortKey="Seyger, Marieke M B" sort="Seyger, Marieke M B" uniqKey="Seyger M" first="Marieke M B" last="Seyger">Marieke M B. Seyger</name><name sortKey="Spuls, Phyllis I" sort="Spuls, Phyllis I" uniqKey="Spuls P" first="Phyllis I" last="Spuls">Phyllis I. Spuls</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Flohr, Carsten" sort="Flohr, Carsten" uniqKey="Flohr C" first="Carsten" last="Flohr">Carsten Flohr</name></region><name sortKey="Ardern Jones, Michael R" sort="Ardern Jones, Michael R" uniqKey="Ardern Jones M" first="Michael R" last="Ardern-Jones">Michael R. Ardern-Jones</name><name sortKey="Brown, Sara J" sort="Brown, Sara J" uniqKey="Brown S" first="Sara J" last="Brown">Sara J. Brown</name><name sortKey="Cork, Michael J" sort="Cork, Michael J" uniqKey="Cork M" first="Michael J" last="Cork">Michael J. Cork</name><name sortKey="Irvine, Alan D" sort="Irvine, Alan D" uniqKey="Irvine A" first="Alan D" last="Irvine">Alan D. Irvine</name><name sortKey="Reynolds, Nick J" sort="Reynolds, Nick J" uniqKey="Reynolds N" first="Nick J" last="Reynolds">Nick J. Reynolds</name></country><country name="France"><region name="Pays de la Loire"><name sortKey="Barbarot, Sebastien" sort="Barbarot, Sebastien" uniqKey="Barbarot S" first="Sebastien" last="Barbarot">Sebastien Barbarot</name></region><name sortKey="Nosbaum, Audrey" sort="Nosbaum, Audrey" uniqKey="Nosbaum A" first="Audrey" last="Nosbaum">Audrey Nosbaum</name><name sortKey="Stalder, Jean Francois" sort="Stalder, Jean Francois" uniqKey="Stalder J" first="Jean-Francois" last="Stalder">Jean-Francois Stalder</name></country><country name="Danemark"><noRegion><name sortKey="Deleuran, Mette" sort="Deleuran, Mette" uniqKey="Deleuran M" first="Mette" last="Deleuran">Mette Deleuran</name></noRegion><name sortKey="Thyssen, Jacob P" sort="Thyssen, Jacob P" uniqKey="Thyssen J" first="Jacob P" last="Thyssen">Jacob P. Thyssen</name><name sortKey="Vestergaard, Christian" sort="Vestergaard, Christian" uniqKey="Vestergaard C" first="Christian" last="Vestergaard">Christian Vestergaard</name></country><country name="Suisse"><noRegion><name sortKey="Bieber, Thomas" sort="Bieber, Thomas" uniqKey="Bieber T" first="Thomas" last="Bieber">Thomas Bieber</name></noRegion><name sortKey="Traidl Hoffmann, Claudia" sort="Traidl Hoffmann, Claudia" uniqKey="Traidl Hoffmann C" first="Claudia" last="Traidl-Hoffmann">Claudia Traidl-Hoffmann</name></country><country name="Allemagne"><region name="Schleswig-Holstein"><name sortKey="Foelster Holst, Regina" sort="Foelster Holst, Regina" uniqKey="Foelster Holst R" first="Regina" last="Foelster-Holst">Regina Foelster-Holst</name></region><name sortKey="Schmitt, Jochen" sort="Schmitt, Jochen" uniqKey="Schmitt J" first="Jochen" last="Schmitt">Jochen Schmitt</name><name sortKey="Van Der Schaft, Jorien" sort="Van Der Schaft, Jorien" uniqKey="Van Der Schaft J" first="Jorien" last="Van Der Schaft">Jorien Van Der Schaft</name><name sortKey="Wollenberg, Andreas" sort="Wollenberg, Andreas" uniqKey="Wollenberg A" first="Andreas" last="Wollenberg">Andreas Wollenberg</name></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Su, John C" sort="Su, John C" uniqKey="Su J" first="John C" last="Su">John C. Su</name></region></country><country name="Brésil"><region name="État de São Paulo"><name sortKey="Takaoka, Roberto" sort="Takaoka, Roberto" uniqKey="Takaoka R" first="Roberto" last="Takaoka">Roberto Takaoka</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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